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Annals of Clinical and Laboratory Science, Vol 9, Issue 4, 343-346
Copyright © 1979 by Association of Clinical Scientists

Articles

Dopamine-beta-hydroxylase effectors in neuroblastoma

MA Brewster and DH Berry

Investigation of dopamine-beta-hydroxylase (DBH) serum activity as a potential diagnostic/prognostic tool for neuroblastoma did not confirm previous reports. However, age-dependent differences in normal children's DBH "activation" by water dilution +/- copper addition was revealed. These findings of age-related DBH effector differences suggest that the strong age relationship of DBH activity may be due to alterations in effectors. Additionally, these effectors may be variably affected by assay methodology, influencing DBH results obtained in neuroblastoma and other disease states.


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X. Zhou, M. G. Espey, J. X. Chen, L. J. Hofseth, K. M. Miranda, S. P. Hussain, D. A. Wink, and C. C. Harris
Inhibitory Effects of Nitric Oxide and Nitrosative Stress on Dopamine-beta -Hydroxylase
J. Biol. Chem., July 7, 2000; 275(28): 21241 - 21246.
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