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Annals of Clinical and Laboratory Science, Vol 8, Issue 6, 472-475
Copyright © 1978 by Association of Clinical Scientists

Articles

Monoclonal gammopathy associated with multiple sclerosis

SH Tsung

A 52-year-old white male with a 26 year history of multiple sclerosis developed a monoclonal gammopathy of the IgA class, with reciprocal depression of normal immunoglobulins. A bone marrow aspirate and biopsy showed a marked increase in plasma cells, many of which appeared immature. These findings fulfilled the diagnostic criteria for multiple myeloma. The association of multiple myeloma with multiple sclerosis may not be coincidental. Mechanisms regarding this association are discussed.


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S Deftereos, D Farmakis, A Papadogianni, B Besleme, E Diamanti-Kandarakis, E Polymeropoylos, D Georgonikou, and A Aessopos
Waldenstrom's macroglobulinemia developing in a patient with multiple sclerosis: coincidence or association?
Multiple Sclerosis, October 1, 2004; 10(5): 598 - 600.
[Abstract] [PDF]


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