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Annals of Clinical and Laboratory Science, Vol 8, Issue 3, 239-243
Copyright © 1978 by Association of Clinical Scientists

Articles

Protein binding of drugs

AF Heald and SM Singhvi

Basic considerations involved in the interaction of drugs with proteins are reviewed. The important role of the concentration of unbound drug in determining therapeutic and toxicologic effects is emphasized. Ultra-filtration is suggested to be the method of choice for the determination of concentrations of unbound drug in plasma in clinical practice.




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Copyright © 1978 by the Association of Clinical Scientists.