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Annals of Clinical and Laboratory Science, Vol 8, Issue 1, 30-33
Copyright © 1978 by Association of Clinical Scientists

Articles

Inhibition of human neutrophil chemotaxis by corticosteroids

C Shea and ED Morse

A direct inhibitory effect of hydrocortisone on granulocyte chemotaxis has been demonstrated with an increasing inhibition between concentrations of 5 microgram to 12.5 microgram per ml. Washing the granulocytes after incubation with hydrocortisone did not reverse the inhibitory effect on chemotaxis indicating a direct cellular effect. Bacteriocidal capacity of the hydrocortisone treated cells was not reduced. These studies indicate corticosteroids, alter motility of granulocytes irreversibly possibly by incorporation into the cell membrane.


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H. H. Kay, I. M. Bird, C. L. Coe, and D. J. Dudley
Antenatal Steroid Treatment and Adverse Fetal Effects: What Is the Evidence?
Reproductive Sciences, September 1, 2000; 7(5): 269 - 278.
[Abstract] [PDF]


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