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Association of Interleukin-10 Gene Polymorphism with Cachexia in Chinese Patients with Gastric Cancer

Address correspondence to Dr. Dianliang Zhang, Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao 266003, Shandong Province, P. R. China; tel 86 532 8291 1324; fax 86 532 8279 0962; e-mail: phdzdl{at}yahoo.com.

This study investigated whether the single nucleotide polymorphisms (SNPs) and haplotypes of interleukin-10 (IL-10) were associated with cachexia in 223 Chinese patients with gastric cancer diagnosed by histopathological examination. Genomic DNA was extracted from peripheral blood leukocytes. The SNPs at positions –1082A/G, –819T/C, and –592A/C in the IL-10 gene promoter were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant differences were found in the allele and genotype frequencies of –592A/C in patients with or without cachexia. Increased frequency of the –1082G allele was found in patients with cachexia (OR = 1.83, 95% CI, 1.00–3.33, p = 0.049). In a logistic regression analysis adjusted for body weight, carcinoma location, and stage, the –1082AG genotype was associated with an odds ratio of 1.989 (95% CI, 1.041–3.802, p = 0.037) for cachexia. The –819CC genotype was associated with an odds ratio of 3.393 (95% CI, 1.298–8.871, p = 0.013) for cachexia. Furthermore, haplotype analysis revealed that the G¹⁰⁸²C⁸¹⁹C⁵⁹² haplotype was associated with increased risk of cachexia as compared to the A¹⁰⁸²T⁸¹⁹A⁵⁹² haplotype (OR = 2.21; 95% CI, 1.14 – 4.30; p = 0.02). Our results suggest that genetic polymorphisms of IL-10 contribute to the susceptibility to cachexia in patients with gastric cancer in the Chinese population.

Keywords: interleukin-10, single nucleotide polymorphisms, haplotype analysis, gastric cancer, cachexia

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