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Annals of Clinical & Laboratory Science 40:49-52 (2010)
© 2010 Association of Clinical Scientists

Discrepancies Between Two Automated Immunoassay Systems in Determining Hepatitis B Virus Markers in Serum Samples with Concomitant Presence of Antigens and Antibodies

Liming Cheng, Qing Guan, Junxia Zhang and Ziyong Sun
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Address correspondence to Ziyong Sun, M.D., Department of Laboratory Medicine, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China; tel 86 27 8366 3639; e-mail hjim75{at}163.com.

This study compared the assay results of HBV markers obtained with two automated immunoassay systems in serum samples with concomitant HBV antigens and antibodies. Eighty-nine samples of concomitant HBsAg and anti-HBs and 74 samples of concomitant HBeAg and anti-HBe were analyzed by the Abbott Architect i2000 and the Roche Elecsys 2010 immunoassay systems. The overall concordance rates of the Architect and Elecsys results were 78.6% for samples with concomitant HBsAg and anti-HBs and 77% for samples with concomitant HBeAg and anti-HBe. The data show that substantial differences exist between the results obtained by these two systems, especially in determining anti-HBs and HBeAg at low concentrations.

Keywords: hepatitis B viral markers, HBsAg, HBeAg, anti-HBs, anti-HBe






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