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Annals of Clinical & Laboratory Science 39:192-195 (2009)
© 2009 Association of Clinical Scientists

Case Report

Anti-Tumor Necrosis Factor-alpha Therapy Provokes Latent Leishmaniasis in a Patient with Rheumatoid Arthritis

Gillian Franklin1, Joel Greenspan2 and Sheng Chen1
1 Departments of Pathology and 2 Medicine, Long Island Jewish Medical Center, The Long Island Campus of Albert Einstein College of Medicine, New Hyde Park, New York

Address correspondence to Sheng Chen, M.D., Ph.D., Department of Pathology, Long Island Jewish Medical Center, 270-05 76th Avenue, New Hyde Park, NY 11040, USA; tel 718 470 7490; fax 718 347 9171; e-mail schen{at}nshs.edu.

It has been reported that anti-tumor necrosis factor-{alpha} therapy increases the risk of opportunistic infections including rare case reports of leishmaniasis. Here we report a case of latent cutaneous leishmaniasis, which was provoked by anti-tumor necrosis factor-{alpha} therapy in a patient with rheumatoid arthritis.

Keywords: anti-TNF-{alpha} monoclonal antibody, adalimumab, leishmaniasis, rheumatoid arthritis






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