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Annals of Clinical & Laboratory Science 39:150-154 (2009)
© 2009 Association of Clinical Scientists

Changes in Total CO2 Measurement According to Reagent Cassette Rotation in Chemistry Autoanalyzers

Hee-Jung Chung1, Woochang Lee1, Sail Chun1, So Young Kang2, Woo In Lee2, Hae-Il Park3 and Won-Ki Min1
1 Departments of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 2 The East-West Neo Medical Center, Kyung Hee University College of Medicine, and 3 College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Address correspondence to Won-Ki Min, M.D., Ph.D., Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, Republic of Korea; tel 82 2 3010 4503; fax: 82 2 478 0884; e-mail wkmin{at}amc.seoul.kr.

The quality control (QC) failure rate in the serum total carbon dioxide (TCO2) test increases at a higher rate than in other tests over time after calibration. The causes of the increased QC failure rate in the TCO2 test were examined. Using a TBA200RF analyzer (Toshiba Medical Systems), the TCO2 of the QC material was measured at 2-hr intervals and was found to decrease by up to 16.5% at 10 hr after calibration. In contrast, using the P-module and D-module analyzers (Roche Diagnostics), the TCO2 of the QC material did not change significantly during 10 hr after calibration. When the TCO2 level of the QC material was measured hourly over 5 hr with the TBA200FR analyzer while the reagent bottle was rotated at 0, 80, 120, 160, or 200 rpm, the rate of decline of TCO2, increased over time after calibration and with increasing reagent cassette rotation. Therefore, in a clinical laboratory using an automated analyzer with a rotating reagent cassette, it is necessary to set a limit to the calibration time interval in order to satisfy the QC goal.

Keywords: carbon dioxide assay, clinical chemistry automated analyzers, quality control






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