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Annals of Clinical & Laboratory Science 39:71-75 (2009)
© 2009 Association of Clinical Scientists

Effect of the Synaptic Scaffolding Protein Homer1a on Chronic Compression of Dorsal Root Ganglion

Zheng-Liang Ma, Wei Zhu, Wei Zhang and Xiao-ping Gu
Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing, Jiangsu Province, China

Address correspondence to Dr. Zheng-Liang Ma, Department of Anesthesiology, Drum Tower Hospital, Medical Department of Nanjing University, Nanjing 210008, Jiangsu Province, China; tel 86 25 8330 4616; fax 86 25 8331 7016; e-mail mazhengliang1964{at}yahoo.com.cn.

Activity-dependent plasticity in the spinal dorsal horn may underlie the development of neuropathic pain following peripheral nerve injury. A product of an immediate early gene (IEG), the synaptic scaffolding protein Homer1a, has received increasing attention because it appears to play a critical role in synaptic plasticity. In this study, we explored the early expression of Homer1 gene in the spinal dorsal horn by using the neuropathic pain model of chronic compression of dorsal root ganglion (CCD). The levels of Homer1a mRNA in the ipsilateral dorsal horn of CCD rats were markedly increased at 4 hr, remained elevated at 8 hr, and then returned to baseline values by 24 hr after CCD treatment. In contrast, there were no significant changes of Homer1a expression in the Sham-operated or Control groups. Significant thermal hyperalgesia appeared at 24 hr post-operation in the CCD rats, but not in the Sham-operated or Control groups. These data show that CCD induces a transient and rapid increase in Homer1a expression in the spinal dorsal horn. These data also suggest that the transient and rapid increase in Homer1a expression may play an important role in the thermal hyperalgesia elicited by neural injury.

Keywords: spinal dorsal root ganglion compression, Homer1a, synaptic plasticity, neuropathic pain






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