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Annals of Clinical & Laboratory Science 39:60-63 (2009)
© 2009 Association of Clinical Scientists

Sophorolipids as Antibacterial Agents

Joseph N. Sleiman1, Stephan A. Kohlhoff1, Patricia M. Roblin1, Sabine Wallner2, Richard Gross2, Margaret R. Hammerschlag1, Michael E. Zenilman3 and Martin H. Bluth4
1 Department of Pediatrics and 3 Surgery, SUNY Downstate Medical Center, Brooklyn, New York; 2 Polytechnic University, Brooklyn, New York; 4 Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan

Address correspondence to Martin H. Bluth, M.D., Ph.D, Department of Pathology, 8203 Scott Hall, Wayne State University School of Medicine, 540 E. Canfield, Detroit, MI 48201, USA; tel 313 577 1102; fax 313 577 0057; e-mail mbluth{at}med.wayne.edu.

Sophorolipids (SLs), glycolipids produced by yeasts, have been reported to have immunomodulating activity and to reduce the mortality rate in animal models of sepsis. In the present study, the antibacterial activities of SLs and several derivatives were tested against a selection of standard bacterial isolates using the broth microdilution method. The SL derivatives tested did not show any significant antibacterial activity in vitro when tested at clinically relevant concentrations. Most likely the reported decrease of mortality rate in the rat septic shock model was not secondary to antibacterial activity of SLs. The SLs may be used as anti-inflammatory agents or immunomodulators without affecting the host’s bacterial flora.

Keywords: sophorolipids, glycolipids, anti-bacterial agents, anti-inflammatory agents






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