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Annals of Clinical & Laboratory Science 38:132-137 (2008)
© 2008 Association of Clinical Scientists

Ischemia Modified Albumin, a Marker of Acute Ischemic Events: A Pilot Study

Sameer S. Talwalkar, Marjorie Bon-Homme, James J. Miller and Ronald J. Elin
Department of Pathology and Laboratory Medicine, University of Louisville Medical School, Louisville, Kentucky

Address correspondence to Ronald J. Elin, M.D, Ph.D., Dept. of Pathology and Laboratory Medicine, Univ. of Louisville Hospital, 530 South Jackson Street, Louisville, KY 40202, USA; tel 502 852 4464; fax 502 852 8299; e-mail rjelin01{at}gwise.louisville.edu.

Ischemia modified albumin (IMA) is a relatively new marker for evaluating patients with cardiac ischemia. Data are emerging on its potential role in non-cardiac ischemic events. In this pilot study we evaluated the utility of IMA in diagnosing acute coronary syndromes (ACS), assessed its role in the diagnosis of non-cardiac ischemia, and correlated its efficacy with troponin T (TnT). Serum levels of IMA were measured in 89 sequential patients who presented to the emergency room with chest pain for which serum TnT was ordered. The patients were classified into 4 groups based on their IMA and TnT results and discharge diagnoses. The data were analyzed with Fischer’s exact test. Multivariate logistic regression analysis relating acute coronary syndrome (ACS) to the combination of TnT and IMA was also performed. The results showed that IMA was a useful marker for the diagnosis of ACS. There was a significant relationship between TnT and IMA (p = 0.032), suggesting that both these biomarkers added significant information about the presence of ACS (p = 0.028) and may be useful for triage of patients who present to the emergency room with chest pain. Serum IMA was also increased in a small proportion of patients with symptoms of stroke, suggesting that it should be considered a marker of acute ischemic events and not specific for cardiac ischemia.

Keywords: chest pain, troponin T, ischemia modified albumin, acute coronary syndrome, stroke






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