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Annals of Clinical & Laboratory Science 37:343-348 (2007)
© 2007 Association of Clinical Scientists

Low Serum LDL Cholesterol Levels and the Risk of Fever, Sepsis, and Malignancy

Renana Shor1, Julio Wainstein2, David Oz1, Mona Boaz3, Zipora Matas4, Asora Fux4 and Aaron Halabe1
1 Departments of Internal Medicine, 2 Diabetes, 3 Statistics, and 4 Biochemistry, The Edith Wolfson Medical Centre, Sackler School of Medicine, Tel Aviv University, Holon, Israel

Address correspondence to Aaron Halabe, M.D., Wolfson Medical Center, PO Box 5, Holon 58100, Israel; fax: 972 3 502 8382; e-mail: halabe{at}wolfson.health.gov.il.

Lipid lowering therapy of serum LDL cholesterol (LDL) has proved beneficial in reducing cardiovascular morbidity and mortality. Lately the recommended target LDL level in very high risk patients was reduced to <70 mg/dl, raising the question of what the price of such a low level will be. To elucidate this concern, we investigated the associations of low serum LDL cholesterol levels (≤ 70 mg/dl) and the incidences of fever, sepsis, and malignancy. Retrospective analysis of 203 patients’ charts was carried out. Patients were divided into 2 groups: Group 1 (n = 79) had serum LDL levels ≤ 70 mg/dl, while Group 2 (n = 124) had levels >70 mg/dl. The first group demonstrated increased odds of hematological cancer by more than 15-fold (OR 15.7, 95% CI 1.78–138.4, p = 0.01). Each 1 mg/dl increase in LDL was associated with a relative reduction of 2.4% in the odds of hematological cancer (OR 0.976, 95% CI 0.956–0.997, p = 0.026). Low LDL levels also increased the odds of fever and sepsis between the groups (OR 5.3, 95% CI 1.8–15.7, p = 0.02). In summary, low serum LDL cholesterol level was associated with increased risks of hematological cancer, fever, and sepsis.

Keywords: LDL cholesterol, malignancy, sepsis, oxidized LDL






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