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Annals of Clinical & Laboratory Science 37:335-342 (2007)
© 2007 Association of Clinical Scientists

Gender Influence on Postprandial Lipemia in Heterozygotes for Familial Hypercholesterolemia

Genovefa D. Kolovou1, Katherine K. Anagnostopoulou1, Dimitris S. Damaskos1, Constantinos Mihas2, Sofia Mavrogeni1, George Hatzigeorgiou1, Theodor Theodoridis3, Dimitri P. Mikhailidis4 and Dennis V. Cokkinos1
1 First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece; 2 Internal Medicine Department, General Hospital, Kimi, Greece; 3 Hematology Department, Evagelismos Hospital, Athens, Greece; and 4 Department of Clinical Biochemistry, Royal Free Hospital, Royal Free and University College Medical School, London, UK

Address correspondence to Genovefa D. Kolovou, M.D., Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece; tel 30 210 949 3520; fax 30 210 949 3336; e-mail: genovefa{at}kolovou.com.

The aim of this study was to evaluate the influence of gender differences on triglyceride (TG) response after a fatty meal in clinically defined heterozygous (h) patients with familial hypercholesterolemia (FH). Nineteen hFH men were age-matched with an equal number of premenopausal women. Plasma TG was measured before and 2, 4, 6, and 8 hr after a standardized fat load. The men with hFH had a greater body mass index (BMI) than hFH women. An abnormal postprandial response was observed in 63% and 16% of hFH men and women, respectively. The mean TG-area under the curve value was higher in hFH men compared to hFH women. Both gender (p = 0.032) and BMI (p = 0.006) equally affected postprandial TG response, but fasting TG levels (p <0.001) were the main determinant. In summary, hFH men have higher BMI, fasting TG level, and postprandial TG level, compared to age-matched premenopausal hFH women, which may partially explain the earlier onset of coronary heart disease in hFH men.

Keywords: familial hypercholesterolemia, coronary heart disease, postprandial lipemia, men vs women




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G. D. Kolovou and H. G. Bilianou
Influence of Aging and Menopause on Lipids and Lipoproteins in Women
Angiology, August 1, 2008; 59(2_suppl): 54S - 57S.
[Abstract] [PDF]


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