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Annals of Clinical & Laboratory Science 37:96-101 (2007)
© 2007 Association of Clinical Scientists

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Antioxidant Vitamin Supplementation in Asthma

Graziano Riccioni1, Mancini Barbara1, Tonino Bucciarelli2, Carmine di Ilio2 and Nicolantonio D’Orazio1
1 Human Nutrition, Department of Biomedical Sciences, G. D’Annunzio University, and 2 Biochemical Clinic, Department of Biomedical Sciences, University of Chieti, Chieti, Italy

Address correspondence to Graziano Riccioni, M.D., PhD., Via G. De Rogatis 12, CP 188, San Severo (FG) 71016, Italy; tel 39 333 636 6661; fax 39 088 222 7022; e-mail griccioni{at}hotmail.com.

The influence of nutrition on chronic bronchial asthma has an important place in the management of this disease. Evidence suggests that specific inflammatory abnormalities exist in the airways of subjects suffering from mild-to-moderate persistent asthma, in whom an inflammatory state is often associated with increased generation of reactive oxygen species and the damaging effects of free radicals. For this reason oxidant stress may be an important pathogenic factor in the progress of the disease. The role of nutrition in bronchial asthma is related to antioxidant vitamins A, C, and E. By counteracting oxidants and reducing external attacks (bacteria, virus, toxins, xenobiotics) in the lung, antioxidant vitamins modulate the development of asthma and the impairment of pulmonary function. Dietary studies suggest relations between oxidative stress, bronchial inflammation, development of asthmatic symptoms, and reduction of cellular functions. Dietary interventions may reduce oxidant stress and prevent or minimize asthmatic symptoms. Such interventions may provide a cost-effective approach to asthma management that may supplement current pharmacological strategies, although this conclusion is not supported by many randomized, placebo-controlled studies. The aim of this short review is to summarize current knowledge regarding the relations between antioxidant vitamins and the treatment of bronchial asthma.

Keywords: asthma, vitamins A, C, and E, antioxidants, free radicals




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