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Annals of Clinical & Laboratory Science 37:57-62 (2007)
© 2007 Association of Clinical Scientists

Serum Transferrin Receptor Status of Healthy Adult Arabs

Huxley Knox-Macaulay1, David Gravell2 and Frances Elender3
1 Department of Haematology, College of Medicine and 2 University Hospital, Sultan Qaboos University, Muscat, Sultanate of Oman; 3 Research & Development Department, West Suffolk Hospital, Bury St. Edmunds, Suffolk, United Kingdom

Address correspondence to Huxley Knox-Macaulay, M.D., 7, The Green, Stanstead, Sudbury, Suffolk, CO10 9AS, UK; tel & fax 01787 280991; e-mail knox.macaulay{at}virgin.net.

Several studies have provided reference ranges for the concentration of serum transferrin receptor (sTfR) in various white populations, but there is a dearth of relevant reference sTfR data in non-whites. The aim of this investigation was to establish sTfR reference ranges and mean values for a healthy non-white Arab population that could be used also for Arabs worldwide. sTfR and serum ferritin concentrations were estimated by immunoassays and blood counts were determined by conventional methods. Analysis of the data of 114 volunteer Arab blood donors (91 male, 23 female) revealed a higher mean sTfR concentration in males of 22.6 ± 8.1 nmol/L (range 10.9–38.7 nmol/L) compared to that in females of 18.7 ± 4.4 nmol/L (range 10.7–25.8 nmol/L, p = 0.001). There was no significant correlation of sTfR concentration with age, serum ferritin level, or blood haemoglobin level, but a strong inverse correlation was demonstrated with mean cell volume and mean cell haemoglobin of red cells. Iron-replete volunteer subjects with {alpha}–thalassaemia trait appear to have relatively high mean sTfR concentration. We recommend the use of gender-dependent sTfR reference values for Arabs.

Keywords: serum transferrin receptor, serum ferritin, erythrocyte indices, Arab population






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