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Annals of Clinical & Laboratory Science 37:49-56 (2007)
© 2007 Association of Clinical Scientists

Early Treatment with Hydroxyethyl Starch 130/0.4 Causes Greater Inhibition of Pulmonary Capillary Leakage and Inflammatory Response than Treatment Instituted Later in Sepsis Induced by Cecal Ligation and Puncture in Rats

Xiaomei Feng1, Yimin Hu1, Jingjing Ding2, Yali Ge3, Juan Song3, Qing Ai1, Zhijie Zhang1 and Jianguo Xu1
1 Departments of Anesthesiology and 2 Pulmonary Disease, Jinling Hospital, Nanjing University School of Medicine, Nanjing; 3 Department of Anesthesiology, Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medial College, People’s Republic of China

Address correspondence to: Jianguo Xu, M.D., Department of Anesthesiology, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, P. R. China; tel 86 25 8480 6839; fax: 86 25 8480 6839; e-mail leaflet1981{at}gmail.com.

This study investigated the temporal profile of effects of hydroxyethyl starch (HES) 130/0.4 on pulmonary capillary leakage in a rat sepsis model induced by cecal ligation and puncture (CLP). Arterial blood pressure and heart rate were monitored during the experiment. Pulmonary capillary leakage was evaluated at 6, 12, 18, and 24 hr after CLP, and HES 130/0.4 was infused iv 2 hr prior to each time point. Myeloperoxidase (MPO) activity of lung homogenates and pulmonary levels of tumor necrosis factor alpha (TNF-{alpha}), interleukin (IL)-6, IL-10, and nuclear factor-kappaB (NF-{kappa}B) activity were measured. Infusion of HES 130/0.4 attenuated the pulmonary capillary leakage, reduced the elevations of MPO, TNF-{alpha}, IL-6, and NF-{kappa}B levels, and further increased the IL-10 level. Infusion of HES 130/0.4 at 4 or 10 hr after the septic insult resulted in the greatest decreases in inflammatory mediators, suggesting that HES 130/0.4 is more protective against pulmonary capillary leakage when given early rather than later during sepsis.

Keywords: hydroxyethyl starch, lung capillary leakage, NF-{kappa}B, TNF-{alpha}, IL-10






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