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Annals of Clinical & Laboratory Science 36:479-484 (2006)
© 2006 Association of Clinical Scientists

Case Report

Polyclonal Plasma Cell Proliferation with Marked Hypergammaglobulinemia and Multiple Autoantibodies

Lin Li1,*, Peihong Hsu2,*, Keyur Patel2, Yasi Saffari2, Ida Ashley3 and Judith Brody1
1 Department of Pathology and Laboratory Medicine, North Shore University Hospital, Manhasset, NY, 2 Department of Pathology and Laboratory Medicine, Long Island Jewish Medical Center, New Hyde Park, NY, and 3 Great Neck Hematology and Oncology, Great Neck, NY

Address correspondence to Judith Brody, M.D., Department of Pathology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA; tel 516 562 4180; fax 516 562 4591; e-mail jbrody{at}nshs.edu.

A 77-yr-old man presented with marked peripheral blood and bone marrow plasmacytosis, marked hypergammaglobulinemia, and multiple autoantibodies. Serum protein immunofixation and immunophenotyping of bone marrow plasma cells by flow cytometry and immunohistochemistry disclosed polyclonal proliferation of plasma cells at various stages of differentiation. The presence of multiple autoantibodies in the patient’s serum suggests that an autoimmune disease underlies the polyclonal proliferation of plasma cells.

Keywords: polyclonal plasmacytosis, hypergammaglobulinemia, autoantibodies, immunoelectrophoresis, flow cytometry, immunohistochemistry






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