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Annals of Clinical & Laboratory Science 36:333-340 (2006)
© 2006 Association of Clinical Scientists

Experimental Ischemic Cardiomyopathy: Insights into Remodeling, Physiological Adaptation, and Humoral Response

Gabriella Agnoletti1, Anna Cargnoni2, Laura Agnoletti2, Marco Di Marcello3, Piera Balzarini4, Evasio Pasini2, Gianluca Gitti2, Patrizia Martina2, Roberta Ardesi2 and Roberto Ferrari5
1 Necker Enfants Malades, Paris, France; 2 Cardiovascular Pathophysiology Center, Salvatore Maugeri Foundation, IRCCS, Gussago, Italy; 3 Veterinary Hospital, Cellatica, Brescia, Italy; 4 II Pathology Institute, University of Brescia, Brescia, Italy; and 5 Department of Cardiology, University of Ferrara, Ferrara, Italy

Address correspondence to Gabriella Agnoletti, M.D., Pediatric Cardiology Service, Groupe Hospitalier Necker Enfants Malades, 149 rue de Sèvres, 75743, Paris, France; tel 33 144 494356; fax 22 144 495724; e-mail gabriella. agnoletti{at}nck.ap-hop-paris.fr.

Ligation of the left anterior descending coronary artery (LAD) is used to induce experimental myocardial infarction (MI). Most previous studies have focused on the early postoperative period, while data on mid-term follow-up are scanty. This study examined the mid-term effects of LAD ligation in 95 MI rats and 28 controls. The following parameters were evaluated: systemic blood pressure (SBP), heart rate (HR), and plasma brain natriuretic peptide (BNP) level. In addition, M-mode and B-mode echocardiography, histologic examinations, and cardiac hydroxyproline assays were performed. Forty-seven perioperative and 5 late deaths were recorded. Left ventricular dilation, observed 1 mo after MI, did not progress with time. Septal thickening was similar in the 2 groups, while wall thickening was lower in the MI rats at 1 mo only. Stroke volume was diminished in MI rats, while cardiac output was depressed only at 1 and 2 mo, due to increased heart rate. SBP was unchanged and plasma BNP level was similar in the 2 groups. The infarcted area (mean ± SD) was 35 ± 10%. The ventricles in MI rats were heavier and had increased hydroxyproline content. In conclusion, these data show that LAD ligation is not only a model of acute MI, but at mid-term it provides a model of chronic ischemic dilated cardiomyopathy.

Keywords: myocardial infarction, chronic ischemia, dilated cardiomyopathy, echocardiography






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