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Annals of Clinical & Laboratory Science 36:267-272 (2006)
© 2006 Association of Clinical Scientists

Increased Serum Neopterin Levels in Women with Polycystic Ovary Syndrome

Burcu Barutcuoglu1, A. Erkin Bozdemir1, Didem Dereli2, Zuhal Parildar1, M. Isil Mutaf1, Dilek Ozmen1 and Oya Bayindir1
1 Departments of Clinical Biochemistry and 2 Internal Medicine, Ege University Medical School, Izmir, Turkey

Address correspondence to Dr. Burcu Barutcuoglu, Department of Clinical Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey; tel 90 232 339 2144; fax 90 232 339 2144; email barutcum{at}yahoo.com.

Polycystic ovary syndrome (PCOS) occurs in 5–10% of premenopausal women. Studies suggest that PCOS is associated with increased risk of coronary heart disease (CHD). To investigate this relationship, 15 PCOS women (group 1) and 10 healthy women (group 2) were studied. Blood leukocyte counts (white blood cells, WBC) and serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, sensitive C-reactive protein (sCRP), and neopterin were measured in the 2 groups. There were no significant differences in serum total cholesterol, HDL-cholesterol, or LDL-cholesterol concentrations between groups 1 and 2. Blood WBC counts and serum levels of neopterin and sCRP were significantly higher in group 1 than group 2. The median (min-max) levels were: WBC, group 1: 8.05 (5.10–9.70) cells x 109/L, group 2: 6.25 (4.70–9.70) cells x 109/L (p <0.01); neopterin, group 1: 10.6 (7.5–49.5) nmol/L, group 2: 9.6 (6.5–12.9) nmol/L (p < 0.05); and sCRP, group 1: 7.0 (1.2–12.0) mg/L, group 2: 2.0 (0.1–12.0) mg/L (p <0.01). This study shows that blood WBC counts and serum sCRP and neopterin levels are significantly elevated in women with PCOS. These findings support an increased risk for early-onset cardiovascular disease in women with PCOS. This is the first report that women with PCOS have higher serum neopterin levels than healthy women with regular menstrual cycles.

Keywords: polycystic ovary syndrome, neopterin, C-reactive protein, cardiovascular disease, WBC count






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