ACLS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hsu, W. T.
Right arrow Articles by Chen, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hsu, W. T.
Right arrow Articles by Chen, B. H.
Annals of Clinical & Laboratory Science 36:174-178 (2006)
© 2006 Association of Clinical Scientists

Effects of Diabetes Duration and Glycemic Control on Free Radicals in Children with Type 1 Diabetes Mellitus

Wan Ting Hsu*, Li Yu Tsai*, Shu Kai Lin, Jen Kuei Hsiao and Bai Hsiun Chen
Department of Laboratory Medicine, Faculty of Medicine, Kaohsiung Medical University, and Chung-Ho Memorial Hospital, Kaohsiung, Taiwan

Address correspondence to Bai Hsiun Chen, M.D., Department of Laboratory Medicine, Kaohsiung Medical University, Chung-Ho Memorial Hospital, No. 100, Shih Chuan 1st Road, Kaohsiung 807, Taiwan; tel 886 7 312 1101 ext 7233; fax 886 7 311 4449; e-mail: chen_bh.tw{at}yahoo.com.tw.

Parameters of lipid peroxidation, protein oxidation, and antioxidant defense systems were measured in blood samples from 47 children with type 1 diabetes mellitus and from 51 healthy controls, matched for age and sex. In the diabetic children, chemiluminescent assay of plasma superoxide anion gave photoemission (counts x 103, mean ± SD) of 674 ± 412, which were significantly higher than those in the controls (452 ± 185; p <0.05). Plasma vitamin A levels in the diabetic children (243 ± 90 µg/dl) were also higher than those in the controls (207 ± 59 µg/dl, p <0.05). In a subgroup of 24 diabetic children with blood HbA1C levels ≥8.5%, plasma lipoperoxide (LPO) and vitamin E levels were higher (p <0.05) than those in 23 diabetic children with blood HbA1C levels <8.5%. In a subgroup of 26 children with diabetes duration ≥5 yr, plasma LPO levels were higher (p <0.05) than those in 21 children with diabetes duration <5 yr. These findings confirm the presence of oxidant stress in children with type 1 diabetes mellitus and demonstrate that certain indices of oxidant stress are influenced by the duration of diabetes and by the efficacy of glycemic control. These observations suggest that supportive therapy aimed at oxidative stress may help to prevent clinical complications in children with type 1 diabetes mellitus.

Keywords: diabetes mellitus type 1, free radicals, superoxide anion, lipoperoxides, vitamins A and E






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Association of Clinical Scientists.