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Comparison of Cardiac Troponin I Levels in Serum and Sodium-Citrate Plasma Using the ACCESS 2 Immunoassay

Address correspondence to Bai-Hsiun Chen, M.D., Department of Laboratory Medicine, Kaohsiung Medical University Hospital, 100 Shih-Chuan 1st Rd., Kaohsiung, Taiwan; tel 886 7 312 1101, x7231; fax: 886 7-311 4449; e-mail chen_bh. tw{at}yahoo.com.tw.

The aim of this study was to determine if sodium-citrate plasma is a suitable substitute for serum for cardiac troponin I (cTnI) measurement using the Beckman ACCESS 2 immunoassay. Linear regression analysis of cTnI levels in paired serum and sodium-citrate plasma samples from 80 patients provided a y-intercept of –0.0193 and a slope of 1.044. The correlation was good [r = 0.995; 95% confidence interval 1.017 to 1.068, p <0.0001]. The paired results were not significantly different by Student’s t-test. Serum and sodium-citrate plasma appear to be interchangeable as samples for cTnI measurement using the ACCESS 2 assay. Furthermore, the use of plasma reduces the turnaround time and may avoid false positive cTnI results due to residual fibrin.

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				D. C Gaze and P. O Collinson Multiple molecular forms of circulating cardiac troponin: analytical and clinical significance Ann Clin Biochem, July 1, 2008; 45(4): 349 - 355. [Abstract] [Full Text] [PDF]