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Annals of Clinical & Laboratory Science 35:413-414 (2005)
© 2005 Association of Clinical Scientists

Brief Communication

p-p70S6K (Thr 389) Expression in Nodular Sclerosing Hodgkin’s Disease as Evidence for Receptor Tyrosine Kinase Signaling

Robert E. Brown1 and Nazmi R. Kamal2
1 Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania; 2 Princess Iman Research and Laboratory Sciences Center, King Hussein Medical Center, Amman, Jordan

Address correspondence to Robert E. Brown, M.D., Anatomic Pathology, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822-0131, USA; tel 570 214 9781; fax 570 271 6105; e-mail: rebrown{at}geisinger.edu.

Platelet-derived growth factor receptor-alpha (PDGFR-{alpha}) expression in the Hodgkin/Reed-Sternberg cells of nodular sclerosing Hodgkin’s disease has been demonstrated in 2 studies. Additional receptor tyrosine kinases have also now been documented. This communication reports the correlative expression in nodular sclerosing Hodgkin’s disease of activated (phosphorylated) p70S6K, one of the putative downstream effectors common to receptor tyrosine kinase signaling.

Keywords: Hodgkin’s disease, p70S6K, receptor tyrosine kinases






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