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Annals of Clinical & Laboratory Science 35:391-396 (2005)
© 2005 Association of Clinical Scientists

Apolipoprotein E Genotype in Matched Men and Women with Coronary Heart Disease

Genovefa D. Kolovou1, Katherine K. Anagnostopoulou1,2, Klelia D. Salpea1,2, Demosthenes B. Panagiotakos3, Ioannis S. Hoursalas2, Marios A. Cariolou4, Katerina Koniavitou2,{dagger} and Dennis V. Cokkinos1
1 First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece; 2 Molecular Immunopathology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece; 3 Harokopio University, Athens, Greece; and 4 Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

Address correspondence to Genovefa D. Kolovou, M.D., Ph.D., Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece; tel 30 210 949 3520; fax 30 210 949 3336; e-mail genkolovou{at}mail.gr.

Apolipoprotein E (apo E) plays an important role in lipid metabolism and its polymorphism may be a risk determinant of coronary heart disease (CHD). Since evidence suggested a gender-specific effect of apo E polymorphism, we studied the influence of gender-specific interaction of the polymorphism on CHD. From a total of 463 Greek Caucasians (314 men and 149 postmenopausal women) with angiographically documented CHD, we selected 79 women (68 ± 9 yr old) and 79 men (66 ± 9 yr old) who were matched for clinical characteristics. Apo E genotyping was performed by PCR and RFLP analysis. Biochemical parameters were also measured. The results were as follows: the E3/3 genotype occurred in 78.5% of the patients, followed by E3/4, E2/3, E2/4, and E4/4 genotypes, which occurred in 9.5%, 9.5%, 1.9%, and 0.6% of the patients, respectively. No significant differences were observed in the apo E allele or apo E genotype distributions between the matched Greek men and women with CHD. The E3/3 men patients were more frequently part of a family with a history of CHD, compared to women (p = 0.035).

Keywords: apolipoprotein E, polymorphism, coronary heart disease, risk stratification




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