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Annals of Clinical & Laboratory Science 35:297-301 (2005)
© 2005 Association of Clinical Scientists

NosocomialTransmission of CTX-M-15 and OXA-30 ß-Lactamase-Producing Escherichia coli in a Neurosurgical Intensive Care Unit

Yang-Ree Kim1, Sang-Il Kim1, Ji-Young Lee2, Yeon-Joon Park3, Kyo-Young Lee3 and Moon-Won Kang1
1 Departments of Internal Medicine, 2 Infection Control, and 3 Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea

Address correspondence to Yeon-Joon Park, M.D., Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St. Mary’s Hospital, 505 Banpo-dong, Seocho-ku, Seoul, 137-701, Korea; tel 82 2 590 1604; fax 82 2 783 6648; e-mail yjpk{at}catholic.ac.kr.

Extended-spectrum ß-lactamase-producing E. coli were recovered from 16 patients in a neurosurgical intensive care unit; surveillance cultures revealed that the organism could be transmitted through the contaminated environment and the hands of health care personnel. All isolates from the patients, environment, and health care personnel showed the same pulsed-field gel electrophoresis pattern. Isoelectric focusing, PCR analysis,and sequencing demonstrated that this E. coli harbored CTX-M-15 and OXA-30 ß-lactamases that were transferred by conjugation. This is the first report of nosocomial transmission caused by E. coli that harbor the combination of CTX-M-15 and OXA-30. This can be a threat because the organisms can hydrolyze cefotaxime, ceftazidime, and cefepime.

Keywords: CTX-M-15, OXA-30, ß-lactamases, Escherichia coli, nosocomial transmission




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[Abstract] [Full Text] [PDF]


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