HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Choi, J. W. Articles by Kim, S. K. Search for Related Content PubMed PubMed Citation Articles by Choi, J. W. Articles by Kim, S. K.

Relationships of Soluble APO-1 (Fas/CD95) Concentrations, Obesity, and Serum Lipid Parameters in Healthy Adults

Address correspondence to Jong Weon Choi, M.D., Ph.D., Department of Laboratory Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon, 400-711, South Korea; tel 82 32 890 2503; fax 82 32 890 2529; e-mail jwchoi{at}inha.ac.kr.

To investigate the relationships of apoptosis with obesity and lipid parameters, we measured serum soluble APO-1 (sAPO-1) concentrations, body mass index (BMI), and serum lipid profiles in 176 healthy adults. Serum sAPO-1 levels were measured by enzyme immunoassay. There were no significant differences in mean sAPO-1 concentrations between men and women, nor between subjects with and without obesity. However, women with high-density lipoprotein cholesterol (HDL-C) <50.2 mg/dl exhibited significantly higher sAPO-1 concentrations than those with HDL-C >50.2 mg/dl (ie, 45.6 ± 10.4 pg/ml vs 31.5 ± 11.3 pg/ml, p <0.05). Serum sAPO-1 concentrations averaged 46.8 ± 10.7 pg/ml in women with serum triglyceride >137.4 mg/dl, which was significantly above the mean value (32.6 ± 12.0 pg/ml, p <0.05) in those with serum triglyceride <137.4 mg/dl. Men with elevated sAPO-1 concentrations showed significantly higher waist-to-hip ratio (WHR) and total body fat (TBF) compared to those with diminished sAPO-1 levels, although no differences were noted in mean values of lipid profiles between the 2 groups of men. Serum sAPO-1 concentrations correlated significantly with HDL-C (r = – 0.41, p <0.05) and triglyceride (r = 0.35, p <0.05) in women and WHR (r = 0.25, p <0.05) and TBF (r = 0.21, p <0.05) in men. In conclusion, serum sAPO-1 appears to have an important relationship to serum lipid levels and body adiposity in healthy adults.

Keywords: serum soluble APO-1, obesity, serum lipids, total body fat, body mass index

This article has been cited by other articles:

				J. W. Choi Reference Intervals of Serum Soluble APO-1 (Fas/CD95) Concentrations in Healthy Adults. Ann. Clin. Lab. Sci., December 1, 2006; 36(1): 103 - 104. [Full Text] [PDF]