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Annals of Clinical & Laboratory Science 35:195-198 (2005)
© 2005 Association of Clinical Scientists

Case Report

Acute Promyelocytic Leukemia with +der(17)t(15;17) Detected by Fluorescence In Situ Hybridization (FISH)

Myungshin Kim1, Jihyang Lim1, Yonggoo Kim1, Kyungja Han1, Seok Lee2 and Chang Kee Min2
1 Departments of Clinical Pathology and 2 Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Address correspondence to Kyungja Han, M.D., Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, 62 Youido-dong, Youngdeungpo-gu, St Mary’s Hospital, Seoul, 150-713, Korea; tel 82 2 3779 1310; fax 82 2 783 6648; e-mail hankja{at}catholic.ac.kr.

Abstract

We describe an unusual case of acute promyelocytic leukemia with +der(17)t(15;17) as the additional cytogenetic abnormality and with t(15;17) defined by fluorescence in situ hybridization (FISH) using a PML/RARA dual color, dual fusion translocation probe. By performing a step-by-step, complementary approach to evaluate unusual chromosomal abnormalities, we detected RARA/PML fusion on a marker chromosome similar to chromosome 17.

Keywords: acute promyelocytic leukemia, PML/RARA, RARA/PML, fluorescence in situ hybridization






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