ACLS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iraz, M.
Right arrow Articles by Fadillioglu, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iraz, M.
Right arrow Articles by Fadillioglu, E.
Annals of Clinical & Laboratory Science 35:169-173 (2005)
© 2005 Association of Clinical Scientists

Brief Communication

Omega-3 Essential Fatty Acid Supplementation and Erythrocyte Oxidant/Antioxidant Status in Rats

Mustafa Iraz1, Hasan Erdogan2, Birsen Ozyurt3, Fikret Ozugurlu4, Salih Ozgocmen5 and Ersin Fadillioglu6
1 Departments of Pharmacology and 6 Physiology, Inonu University Faculty of Medicine, Malatya; 2 Departments of Physiology, 3 Anatomy, and 4 Biochemistry, Gaziosmanpasa University Faculty of Medicine, Tokat; and 5 Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Firat University Faculty of Medicine, Elazig,Turkey

Address correspondence to Mustafa Iraz, M.D., Inonu Universitesi Tip Fakultesi (Dekanlik Binasi), Farmakoloji Anabilim Dali, TR-44280, Malatya, Turkey; tel 90 422 341 0660; fax 90 422 341 0036; e-mail mustafairaz{at}yahoo.com.

Abstract

Fish oil contains large amounts of essential omega-3 fatty acids, such as eicosapentaenoic and docosahexaneoic acids, which are building structures of cell membranes. The goal of this study was to elucidate the effects of dietary omega-3 fatty acid supplementation on the oxidant/antioxidant status of erythrocytes in rats. The malondialdehyde (MDA) and nitric oxide (NO) levels and the catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX) activities were assayed in erythrocytes of male Wistar albino rats after 30 days of dietary supplementation with fish oil (0.4 g/kg/day). Erythrocyte CAT activity in the treated group was increased in comparison with the control group. Erythrocyte MDA and NO levels were lower in the treated group than the controls. Erythrocyte GSH-Px and SOD activities did not differ significantly in the 2 groups. Negative correlations were found between SOD and CAT activities, and between SOD and GSH-Px activities in the treated group. In conclusion, omega-3 fatty acid supplementation helps to prevent lipid peroxidation and to safeguard erythrocytes from oxidative injury. Dietary supplementation with omega-3 fatty acids might possibly protect tissues from oxygen free radical injury in the various diseases in which the oxidant/antioxidant defense mechanisms are disturbed.

Keywords: fish oil, omega-3 essential fatty acids, oxidant/antioxidant st, lipid peroxidation, nitric oxide




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. Gao, J. Wang, K. R. Sekhar, H. Yin, N. F. Yared, S. N. Schneider, S. Sasi, T. P. Dalton, M. E. Anderson, J. Y. Chan, et al.
Novel n-3 Fatty Acid Oxidation Products Activate Nrf2 by Destabilizing the Association between Keap1 and Cullin3
J. Biol. Chem., January 26, 2007; 282(4): 2529 - 2537.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the Association of Clinical Scientists.