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Annals of Clinical & Laboratory Science 35:131-136 (2005)
© 2005 Association of Clinical Scientists

Brief Communication

Morphoproteomic Analysis of Osteolytic Langerhans Cell Histiocytosis with Therapeutic Implications

Robert E. Brown
Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania

Address correspondence to Robert E. Brown, M.D., Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822-0131; tel 570 271 6332; fax 570 271 6105; e-mail rebrown{at}geisinger.edu.

Abstract

Morphoproteomics utilizes immunohistochemistry to identify protein analytes in tumor cells in order to uncover or confirm potential molecular pathways that may be essential to their proliferation, integrity, and histogenesis and that may serve as therapeutic targets. This communication illustrates the application of such an approach to osteolytic Langerhans cell histiocytosis and considers such molecular targets in the context of currently available therapies.

Keywords: Langerhans cell histiocytosis, morphoproteomics






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