ACLS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, S.-K.
Right arrow Articles by Zhong, W.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, S.-K.
Right arrow Articles by Zhong, W.-L.
Annals of Clinical & Laboratory Science 34:443-448 (2004)
© 2004 Association of Clinical Scientists

Association of Apolipoprotein E Genotypes with Serum Lipid Profiles in a Healthy Population of Taiwan

Shu-Kai Lin1, Jau-Tsuen Kao2, Shih-Meng Tsai3, Li-Yu Tsai1,4, Mei-Nung Lin1, Chung-Jen Lai4 and Way-Li Zhong4
1 Department of Clinical Biochemistry, Kaohsiung Medical University, Kaohsiung; 2 School of Medical Technology, National Taiwan University, Taipei; 3 School of Technology for Medical Sciences and 4 Department of Public Health, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Address correspondence to Li-Yu Tsai, Ph.D., Department of Clinical Chemistry, School of Technology for Medical Sciences, Kaohsiung Medical University, No. 100 Shi-Chuan 1st Road, San Ming District, Kaohsiung, Taiwan; tel 886 7 312 1101 ext 7262; fax 886 7 237 0544; e-mail tsliyu{at}kmu.edu.tw.

Apolipoprotein E (apoE, protein; APOE, gene) plays a major role in lipoprotein metabolism and lipid transport. Many investigators have described associations between apoE genotypes, coronary artery disease (CAD), and other risk factors. The aim of this study was to investigate the association between apoE genotypes and serum lipid profiles in a healthy population of 220 volunteers at Kaohsiung in Taiwan. Other CAD risk factors such as serum levels of apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), homocysteine (Hcy), folate, and vitamin B12 were also measured. ApoE genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In the study population, the frequency of apoE allele {varepsilon}3 was greatest (85.2%); the frequency of {varepsilon}2 was 8.4%; and that of {varepsilon}4 was 6.4%. The serum apoA-1/apoB ratio showed significant difference among the 3 apoE genotype groups (p .0001); the apoA-1/apoB ratio was 1.9 ± 0.1 (mean ± SD) in the {varepsilon}2 group, vs 1.4 ± 0.04 and 1.5 ± 0.12 in the {varepsilon}3 and {varepsilon}4 groups, respectively. No significant associations were found between APOE alleles and the serum levels of the various lipids or other CHD risk factors.

Keywords: apolipoproteins E, A-I, B, polymerase chain reaction-restriction fragment length polymorphism




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
G. Ravaglia, P. Forti, F. Maioli, M. Chiappelli, F. Montesi, M. Bianchin, F. Licastro, and C. Patterson
Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly
Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1473 - 1480.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Association of Clinical Scientists.