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Annals of Clinical & Laboratory Science 34:400-404 (2004)
© 2004 Association of Clinical Scientists

Brief Communication

Associations of Serum TRAIL Concentrations, Anthropometric Variables, and Serum Lipid Parameters in Healthy Adults

Jong Weon Choi1, Jung Soo Song2 and Soo Hwan Pai1
1 Department of Laboratory Medicine and 2 Department of Rheumatology/Medicine, College of Medicine, Inha University, Inchon, South Korea

Address correspondence to Soo Hwan Pai, M.D., Department of Laboratory Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon, 400-711, South Korea; tel 82 32 890 2503; fax 82 32 890 2529; e-mail shpaimd{at}inha.ac.kr.

Abstract

To investigate the relationships of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), anthropometric variables, and lipid parameters, we measured serum TRAIL concentrations, body mass index (BMI), total body fat (TBF), and serum lipid profiles in 207 healthy adults. There were no significant differences in serum TRAIL concentrations between men and women, nor between elderly persons and middle-aged subjects. However, men with TBF 16.4 kg (75th per centile) exhibited significantly higher serum TRAIL concentrations than those with TBF 11.2 kg (25th per centile) (69.7 ± 15.1 pg/ml vs 50.2 ± 14.3 pg/ml, p <0.05). Serum TRAIL concentration averaged 76.2 ± 16.1 pg/ml in women with low-density lipoprotein cholesterol (LDL-C) 165 mg/dl (75th per centile), which was significantly above the values (53.1 ± 12.9 pg/ml, p <0.05) in those with LDL-C 117 mg/dl (25th per centile), although no differences were observed on the basis of TBF (75th percentile vs 25th percentile). Serum TRAIL concentrations correlated significantly with TBF (r = 0.31, p <0.05) and lean body mass (r = –0.26, p <0.05) in men and LDL-C (r = 0.32, p <0.05) and total cholesterol (r = 0.21, p <0.05) in women. In conclusion, serum TRAIL concentrations are associated with serum lipid levels and body adiposity in healthy adults, but are unrelated to a subject’s age or gender.

Keywords: tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), total body fat, serum lipid levels, low-density lipoprotein cholesterol






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