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Annals of Clinical & Laboratory Science 34:397-399 (2004)
© 2004 Association of Clinical Scientists

Brief Communication

Morphoproteomic Portrait of the mTOR Pathway in Mesenchymal Chondrosarcoma

Robert E. Brown
Division of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania

Address correspondence to Robert E. Brown, M.D., Division of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822-0131, USA; tel: 570 271 6332; fax: 570 271 6105; e-mail rebrown{at}geisinger.edu.

Abstract

Morphoproteomics is defined as the identification by immunohistochemistry of the molecular circuitry of various proteins in a tumor by noting their state of activation (translocation and phosphorylation) and correlative expressions. Such an approach can uncover or confirm potential molecular targets that may be essential to the growth, integrity, and histogenesis of a particular tumor type and that are amenable to specific therapeutic interventions. This communication illustrates the application of such an approach in depicting the mTOR pathway in mesenchymal chondrosarcoma.

Keywords: mesenchymal chondrosarcoma, morphoproteomics, mTOR pathway






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