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Annals of Clinical & Laboratory Science 34:330-335 (2004)
© 2004 Association of Clinical Scientists

Brief communication

Effects of Different Hyaluronic Acid Products on Synovial Fluid Levels of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Knee Osteoarthritis

Saliha Karatay1, Ahmet Kiziltunc2, Kadir Yildirim1, Rabia Cerrah Karanfil1 and Kazim Senel1
1 Department of Physical Medicine and Rehabilitation and 2 Department of Biochemistry, Medical Faculty, Atatürk University, Erzurum, Turkey

Address correspondence to Dr. Saliha Karatay, Atatürk Üniversitesi, Tip Fakültesi, Fiziksel Tip ve Rehabilitasyon Anabilim Dali, 25240 Erzurum, Turkey; tel 90 442 236 1212/ 1625; fax 90 442 236 1301; e-mail: skaratay73{at}hotmail.com.

Abstract

The aim of this study was to evaluate the effects of different hyaluronic acid (HA) forms on synovial fluid levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) during the treatment of patients with knee osteoarthritis (OA). Forty patients were randomly assigned to 2 groups that were treated with native sodium hyaluronate (group I) or cross-linked hylan G-F 20 (group II). Clinical evaluations and synovial fluid aspirations were performed before the 1st injection (baseline), the 2nd injection (week 1), the 3rd injection (week 2), and at 1 week after the 3rd injection (week 3). Synovial fluid levels of both ICAM-1 and VCAM-1 were significantly reduced at weeks 1 to 3, compared to the baseline values. The Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index was used for clinical evaluations; the WOMAC pain score and physical function score were progressively improved at weeks 1 to 3 in both groups; the WOMAC stiffness score was significantly improved at week 3 in both groups. No significant differences were noted between the 2 treatment groups in respect to ICAM-1 levels, VCAM-1 levels, WOMAC pain score, stiffness score, or physical function score at any time. The decreased ICAM-1 and VCAM-1 levels after intra-articular HA injection may help to explain the anti-inflammatory effects of HA therapy in knee OA.

Keywords: hyaluronic acid, molecular weight, ICAM-1, VCAM-1, knee osteoarthritis, synovial fluid






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