HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by She, R. Articles by Szakacs, J. Search for Related Content PubMed PubMed Citation Articles by She, R. Articles by Szakacs, J.

Hyperostosis Frontalis Interna: Case Report and Review of Literature

Address correspondence to Juliana Szakacs, M.D., Department of Pathology, University of Utah Medical School, 30 N 1900 East, 5C124, Salt Lake City, UT 84132, USA; tel 801 581 2507; fax 801 585 3831; e-mail juliana.szakacs{at}path.utah.edu.

Abstract

Hyperostosis frontalis interna (HFI) has been reported in high frequency among post-menopausal elderly women. Although it was widely discussed in the past, this entity is rarely mentioned in the current pathology literature. We report a postmortem case of a 56 yr-old post-menopausal woman with irregular thickening of the internal surface of the frontal bone. Histology revealed an organized trabecular pattern with overall thickening of the cancellous bone. The periosteum and cortical bone were unaffected. The finding was considered to be unrelated to her death. HFI should be recognized as a benign entity and distinguished from other disorders that involve the frontal skull bone, such as Paget’s disease, acromegaly, and malignancy. The etiology of HFI is unknown, but current hypotheses implicate hormonal stimulation.

Keywords: hyperostosis, skull, Paget’s disease, acromegaly, rickets

This article has been cited by other articles:

				A. J. Waclawik Hyperostosis Frontalis Interna Arch Neurol, February 1, 2006; 63(2): 291 - 291. [Full Text] [PDF]