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Annals of Clinical & Laboratory Science 34:159-164 (2004)
© 2004 Association of Clinical Scientists

Differential Expression of Manganese Containing Superoxide Dismutase in Patients with Breast Cancer in Taiwan

Tze-Kiong Er1, Ming-Feng Hou2, Eing-Mei Tsa3, Jau-Nan Lee3 and Li-Yu Tsai4
1 Graduate Institute of Medicine, 2 Departments of Surgery, 3 Obstetrics/Gynecology, and 4 Clinical Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

Address correspondence to Li-Yu Tsai PhD, Department of Clinical Chemistry, School of Technology for Medical Science, Kaohsiung Medical University, 100 Shi-Chuan 1st Road, San Ming District, Kaohsiung, Taiwan, ROC; tel 886 7 312 1101, ext 7262, 7263; fax 886 7 237 0544; e-mail tsliyu{at}kmu.edu.tw.

This study used Western blot analysis to measure the expression of superoxide dismutases (Mn-SOD and Cu/Zn-SOD) in breast cancer tissues from 57 patients. Mn-SOD expression in the breast cancer tissues averaged 1.5-fold higher than in the adjacent tumor-free tissues (p <0.05). There was no significant difference in Cu/Zn-SOD expression between neoplastic and tumor-free breast tissues. This study shows a significant increase of Mn-SOD expression in breast cancer tissues. The authors speculate that up-regulation of Mn-SOD expression induced by oxidative stress or local inflammation may contribute a selective growth advantage to tumor cells compared to their normal counterparts.

Keywords: breast cancer, Mn-SOD, Cu/Zn-SOD, reactive oxygen species






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