ACLS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tseng, C.-J.
Right arrow Articles by Chu, D.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tseng, C.-J.
Right arrow Articles by Chu, D.-C.
Annals of Clinical & Laboratory Science 34:154-158 (2004)
© 2004 Association of Clinical Scientists

Lack of STK11 Gene Expression in Homozygous Twins with Peutz-Jeghers Syndrome

Chih-Jen Tseng1,{dagger}, Shi-Feng Chen2,{dagger}, Shu-I Liou2, Shu-Chuan Lu3, Jie-Ming Chen2, Chien-Feng Sun3, Shuenn-Dye Chang1, Po-Jen Cheng1, Jui-Der Liou1 and Da-Chang Chu2,3
1 Departments of Obstetrics/Gynecology and 3 Clinical Pathology, Chang Gung Memorial Hospital, Chia-I, Lin-Kou, and Taipai, Taiwan; 2 Graduate Institute of Medical Biotechnology, School of Medical Technology, Chang Gung University, Tao-Yuan, Taiwan

Address correspondence to Da-Chang Chu PhD, Graduate Institute of Medical Biotechnology, School of Medical Technology, Chang Gung University, 259 Wen-Hua 1st Rd, Kwei Shan, Tao-Yuan, 333, Taiwan; tel 886 3 211 8800 ext. 5086; fax 886 3 211 8512; e-mail: dcchu{at}mail.cgu.edu.tw.

Clinical features of Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder, include clusters of melanotic spots on the lips and limbs, polyposis of the gastrointestinal (GI) tract, and propensity to develop neoplasms of the GI tract, ovaries, testes, and other sites. We report twin sisters with PJS who were found to be homozygous, based on analyses of 9 DNA markers containing short tandem repeats (STR). Aberrant expression of a putative tumor suppressor gene, STK11, which encodes a serine threonine kinase, has been suggested as the etiologic factor in PJS. In both of the twin sisters with PJS, mRNA analyses by RT-PCR demonstrated a complete lack of STK 11 gene expression. These results provide direct evidence that STK11 gene expression is abnormal in PJS. Detecting abnormal expression of the STK11 gene may serve as a molecular approach to the diagnosis of PJS and may facilitate genotype-phenotype correlations in PJS patients.

Keywords: Peutz-Jeghers syndrome, STK11 gene expression, ovarian neoplasm, cervical cancer






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Association of Clinical Scientists.