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Identification of a novel O allele in the Taiwanese population^*

Address correspondence to Chien-Feng Sun, M.D., Department of Clinical Pathology, Linkou Medical Center, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kweishan, Taoyuan, 333, Taiwan, ROC; tel 886 3 328 1200, ext 2554; fax 886 3 397 1827; e-mail suncgj{at}adm.cgmh.org.tw.

The ABO system is one of the major blood groups that have significant impact on blood transfusion and paternity testing. We have found a new ABO allele by analyses of the ABO genotype of the Taiwanese population. Exons 6 and 7 of the ABO gene were amplified by the polymerase chain reaction and analyzed by direct sequencing. The results indicated that the ABO gene in the Taiwanese population consists mainly of the A¹, A^1v, B, O¹, and O^1v alleles. In addition, a novel O allele designated as O^Taiwan was identified that has G T substitution at the nucleotide 801 of the O¹ allele. The O^Taiwan allele is inheritable, since it is also present in an offspring of the O^Taiwan–carrying individual. The information presented herein is valuable for population research and for analyses of evolutionary lineage.

Keywords: ABO gene, O^Taiwan allele, direct sequencing, polymerase chain reaction