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Effects of Soy-Protein Diet on Elevated Brain Lipid Peroxide Levels Induced by Simulated Weightlessness

Address correspondence to Parimal Chowdhury, Ph.D., Department of Physiology and Biophysics, Slot # 505, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA; tel 501 686 5443; fax 501 686 8167; e-mail: chowdhuryparimal{at}uams.edu.

Abstract

The influence of soy-protein diet on brain lipid peroxidation in female rats was studied using a tail-suspension model of weightlessness. The study tested the efficacy of diets containing 0% or 11.1% soy-protein in 4 groups of female Sprague Dawley rats that were maintained with or without tail-suspension for a period of 3 weeks. At term, the whole brain was removed, segmented, and analyzed for malondialdehyde (MDA) as an index of lipid peroxidation. Brain levels of MDA were significantly higher in both tail-suspended groups than in the non-suspended control groups on the same diet, (p < 0.05). The high soy-protein diet decreased MDA levels significantly, compared to the 0% soy-protein groups (p < 0.05). Furthermore, MDA levels were significantly lower in the tail-suspended group on high soy-protein diet, compared to the corresponding 0% soy-protein group. In conjunction with previous findings in male rats, these data indicate that tail-suspension increases brain MDA levels in rats regardless of gender, and that a diet rich in soy-protein decreases the brain MDA level in both the non-suspended and tail-suspended groups. These observations imply that the soy-protein diet has a protective antioxidant effect during both the basal condition and the stressful condition.

Keywords: tail-suspension, simulated weightlessness, lipid peroxidation, soy-protein diet, malondialdehyde

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