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Annals of Clinical & Laboratory Science 33:465-470 (2003)
© 2003 Association of Clinical Scientists

Case Report

Mature Cystic Teratoma of the Ovary Associated with Complete Colonic Wall and Mucinous Cystadenoma

Ping Tang1, Solaima Soukkary2 and Ellen Kahn1
Departments of 1 Pathology and 2 Surgery, North Shore University Hospital, Manhasset, New York

Address correspondence to Ellen Kahn, M.D., Department of Pathology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA; tel 516 562 4183; fax 516 562 4591; e-mail:ekahn{at}nshs.edu.

Abstract

Mature cystic teratomas of the ovary frequently contain intestinal type epithelium, but they are rarely associated with complete intestinal wall. The association of mature cystic teratoma with mucinous cystadenoma is not unusual. However, the pathogenetic relationship between these two lesions remains unanswered. We report a mature cystic teratoma of the ovary in a 16-yr old female that contained a complete colonic wall in continuity with an endocervical–type mucinous cystadenoma. Both the mucinous cystadenoma and the colonic wall showed the typical histopathological and immunohistochemical patterns of classical mucinous cystadenoma (positive for CK7, negative for CK20) and normal colonic wall (positive for CK20, negative for CK7), respectively. The microscopic and immunohistochemical patterns of the epithelium from the transitional zone between colonic wall-like structure and mucinous cystadenoma demonstrated features of both types of epithelium, positive for both CK7 and CK20, and focally positive for a neuroendocrine marker, chromogranin, which is normally present in colonic mucosa. These results suggest that the mucinous cystadenoma originated from the colonic epithelium of the mature cystic teratoma.

Keywords: mature cystic teratoma of ovary, mucinous cystadenoma, immunohistochemistry






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