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Annals of Clinical & Laboratory Science 33:429-434 (2003)
© 2003 Association of Clinical Scientists

Polymorphisms of Prostate-Specific Antigen Gene Promoter: Determination From Cord Blood Collected on Filter Paper

Jie Liu1, Jin-San Zhang2, Charles Y. F. Young2 and Pai C. Kao3
1 Guangdong Hematopoietic Stem Cell Therapy Technology Center, Guangzhou, China
2 Section of Urologic Research and 3 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

Address correspondence to Pai C. Kao, Ph.D., Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; tel 507 284 2691; fax 507 284 5036; e-mail kao.pai{at}mayo.edu

Recent studies have shown that a single nucleotide polymorphism of A/G substitution in the androgen response element-1 (ARE-1) of the promoter for the prostate-specific antigen gene is a biomarker of prostate cancer. Portugese men with prostate cancer have a high percentage (43%) of the AA polymorphism of the gene (41% AG, 16% GG), whereas healthy Japanese men have a much lower rate (5%) of the AA polymorphism, (31% AG, 64% GG). The goal of the present study was to see whether or not the Chinese also have a low rate of the AA polymorphism. This study used 94 specimens of cord blood that were the leftover waste of cord blood banking. The samples were collected from Chinese infants onto filter paper, dried, and shipped to Rochester, MN, USA, for PCR amplification and analysis. The observed rate of the AA polymorphism in the samples was very low (5%), with 26% AG, 69% GG. The low incidence of AA polymorphism appears to be a trait of Asians that may reduce their risk of prostate cancer.

Keywords: PSA gene promoter, androgen response element-1, prostate cancer, cord blood, Chinese subjects




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[Abstract] [Full Text] [PDF]


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