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Annals of Clinical & Laboratory Science 33:407-410 (2003)
© 2003 Association of Clinical Scientists

Brief Communication

Erythropoietic Activities in Acute Leukemia and in Malignant Lymphoma with or without Bone Marrow Involvement

Jong Weon Choi and Soo Hwan Pai
Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea

Address correspondence to Jong Weon Choi MD PhD, Department of Laboratory Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon, 400-711, South Korea; tel 82-32-890-2503; fax 82-32-890-2529; e-mail: jwchoi{at}inha.ac.kr.

Abstract

Erythropoietic activities and immature reticulocyte production were investigated in a total of 157 patients (81 men, 76 women, median age = 42 yr, range = 23 to 65 yr) with acute lymphoid leukemia (ALL, n = 31), acute myeloid leukemia (AML, n = 39), or non-Hodgkin’s lymphoma (NHL, n = 87), based on assays of the hemogram, red cell indices, reticulocyte subpopulations, and intramedullary erythroid precursors. There were no significant differences in red blood cell (RBC) counts, blood hemoglobin levels, or erythroid precursors between ALL and AML patients. Reticulocytes in AML patients averaged 1.7 ± 0.8%, which was higher than in patients with ALL (0.8 ± 0.3%, p <0.01); the proportion of high-fluorescence reticulocytes (HFR) averaged 4-fold higher in AML versus ALL (p <0.01) and the reticulocyte maturity index (RMI) was higher in AML (20.8 ± 8.3 %) versus ALL (12.4 ± 6.5%, p <0.01). The RMI was higher in NHL patients with bone marrow (BM) involvement (15.6 ± 9.4%), compared to those without BM involvement (4.3 ± 2.1%, p <0.01). The proportion of HFR averaged 11-fold higher in NHL with BM involvement versus NHL without BM involvement. In summary, erythropoietic activity is significantly more active in patients with AML compared to ALL and in patients with NHL with BM involvement, compared to NHL without BM involvement.

Keywords: acute lymphoid leukemia (ALL), acute myelogenous leukemia (AML), non-Hodgkin’s lymphoma, erythropoiesis






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