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Annals of Clinical & Laboratory Science 33:396-400 (2003)
© 2003 Association of Clinical Scientists

Thromboembolic Risk Factors in Patients Undergoing Kidney Transplant: Implication of Abnormally Short Activated Partial Thromboplastin Time

Nabil G. Guirguis1, Chad Eicher1, Lynette Hock2, James Lynch2, Vicki D. Graham3, P. R. Rajagopalan3, Amal Guirguis3 and John Lazarchick3
1 Internal Medicine Department and 2 Preventive and Societal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska
3 Pathology and Transplantation Departments, Medical University of South Carolina, Charleston, South Carolina

Address correspondence to: John Lazarchick, M.D., Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Suite 309, P.O. Box 250908, Charleston, SC 29425, USA; tel 843 792 2933; fax 843 792 1248; e-mail lazarj{at}musc.edu.

This study was designed to examine the relationship of short activated partial thromboplastin time (aPTT) and prothrombin time (PT) to the incidence of thromboembolic events, hereditary and acquired coagulation defects associated with an increased risk of thrombosis, or cardiovascular diseases in patients undergoing renal transplantation. The prevalence of these conditions in our patients (n = 436) was 55%. Forty-two percent of the patients had short aPTT or PT. Multivariate analysis revealed that patients with short aPTT have an odds ratio (OR) = 2.15, 95% Confidence Interval (CI) (1.27–3.64) (p =0.0042), and for patients with short PT, an OR = 2.01, 95% CI (0.99–4.08) (p = 0.052). Our study also suggests that other risk factors, including non-white ethnicity (98% blacks), OR =1.64, 95% CI (1.01–2.67) (p = 0.047), diabetes mellitus, OR = 2.62, 95% CI (1.11–6.18) (P = 0.028), and autosomal dominant polycystic kidney disease (ADPKD) (p <0.0001). Short aPTT results, or probably short PT results, pre- or post-transplantation may be associated with increased risks for thromboembolism.

Keywords: activated partial thromboplastin time, prothrombin time thromboembolism, renal transplantation






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