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Ultrastructural Findings in Metastatic Bronchioloalveolar Carcinoma

Address correspondence to Steven I. Hajdu, M.D., 4 Forest Court, Syosset, New York, 11791, USA: tel 516 922 5979; fax 516 922 1588.

This study was prompted by the recent revision of the definition of bronchioloalveolar carcinoma (BAC) that defines BAC, light microscopically, as a non-invasive carcinoma. Doubt has been raised whether BACs retain certain specific microscopic features after becoming invasive or metastatic. We studied 7 cases of metastatic, non-mucinous BAC by electron microscopy. Of these cases, 5 showed Clara cell granules and 1 revealed lamellar bodies. The remaining case did not show ultrastructural features of BAC. These findings suggest that most BACs retain some of their ultrastructural features after becoming metastatic neoplasms.

Keywords: Metastatic bronchioloalveolar carcinoma, invasive bronchioloalveolar carcinoma, electron microscopy, Clara cell granules, lamellar inclusions

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				S. I. Hajdu The Story of Bronchioloalveolar Carcinoma Ann. Clin. Lab. Sci., January 1, 2005; 35(3): 336 - 338. [Full Text] [PDF]