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Annals of Clinical & Laboratory Science 33:265-270 (2003)
© 2003 Association of Clinical Scientists

Transient Paraproteinemia: An Intriguing Immunological Anomaly

Stephen L. Strobel
Department of Pathology, St. Vincent Mercy Medical Center, Toledo, Ohio

Address correspondence to Stephen L. Strobel, M.D., Department of Pathology, St. Vincent Mercy Medical Center, 2213 Cherry Street, Toledo, OH 46308-2603, USA; tel 419 251 4534; fax 419 251 3846; e-mail stephen_strobel{at}mhsnr.orrg.

Serum transient paraproteins are small monoclonal immunoglobulins that are induced by a self-limiting regulatory defect in the control of certain terminally differentiated B-cell clones. Relatively uncommon and ill-defined in the medical literature, such proteins may be regarded as immunologic anomalies. Their clinical significance and potential impact on patient management are poorly understood. To elucidate this phenomenon, we reviewed the serum transient paraproteins that were encountered in a large community hospital during a 12 mo period. Twelve transient paraproteins were identified in a total of 895 serum protein electrophoreses reviewed (1.3% incidence). The relationships of the transient paraproteins to specific diseases were studied.

Keywords: transient paraprotein, electrophoresis, immunofixation, monoclonal protein, autoimmunity






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