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Annals of Clinical & Laboratory Science 33:156-159 (2003)
© 2003 Association of Clinical Scientists

Serum Free and Bound Sialic Acid and Alpha-1-Acid Glycoprotein in Patients with Laryngeal Cancer

Celil Uslu1, Seyithan Taysi2, Fatih Akcay2, M. Yavuz Sutbeyaz1 and Nuri Bakan2
1 Department of Otorhinolaryngology-Head and Neck Surgery, and 2 Department of Biochemistry, School of Medicine, Atatürk University, Erzurum, Turkey

Address correspondence to Seyithan Taysi, M.D., Department of Biochemistry, Ataturk University Medical School, 25240 Erzurum, Turkey; tel 90 442 236 1212-2220; fax 90 442 1301; e-mail seytaysi{at}hotmail.com.

Serum specimens from 35 patients with laryngeal cancer (10 at stage II; 12 at stage III; 13 at stage IV) were obtained before therapy was initiated. Concentrations of bound sialic acid (BSA), free sialic acid (FSA), and {alpha}-1-acid glycoprotein (AAG) were compared to those in serum specimens from 34 healthy controls. The mean levels of serum BSA and AAG were significantly increased in the laryngeal cancer patients versus the controls; there was no significant difference in serum FSA levels between the patients and controls. Mean serum BSA and AAG levels were lowest in the control group and highest in the stage IV patients. As the stage of the cancer advanced, progressively higher levels of serum BSA and AAG were observed. The results indicate that serum BSA and AAG, but not FSA, show correlation with the stage of laryngeal carcinoma.

Keywords: {alpha}-1-acid glycoprotein, free and bound sialic acid, laryngeal cancer, acute phase reactants




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[Abstract] [Full Text] [PDF]


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