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Annals of Clinical & Laboratory Science 33:149-155 (2003)
© 2003 Association of Clinical Scientists

Monokine Levels in Cancer and Infection

Gi-Soo Shin1, Bong-Hee Lee2, Seong Lee3, Seung-Yun Chung4, Myungshin Kim5, Jihyang Lim5, Yonggoo Kim5, Hi Jeong Kwon5, Chang Suk Kang5 and Kyungja Han5
1 Red Cross College of Nursing, 2 Department of Bioscience, Korea University, and 3 Departments of Surgery, 4 Pediatrics, and 5 Clinical Pathology, College of Medicine, Catholic University of Korea, Seoul, Korea

Address correspondence to Kyungja Han, M.D., Department of Clinical Pathology, Catholic University Medical College, St. Mary’s Hospital, Youngdeungpo-gu, Youido-dong 62, Seoul, Korea (south) 150-713; tel 82 2 3779 1297; fax 82 2 783 6648; e-mail: hankja{at}catholic.ac.kr.

The levels of monocyte intracellular monokines (TNF{alpha}, MIP, and MIG) in patients with cancer or bacterial infection were studied by multiparameter flow cytometry and comparative fluorescence analysis. TNF{alpha}, MIP, and MIG levels in peripheral blood of patients with cancer or bacterial infection were higher than in normal controls (p <0.005). In normal controls, no significant relationships were found among TNF{alpha}, MIG, MIP levels, monocyte count, and lymphocyte count in peripheral blood. In cancer patients, TNF{alpha} was strongly related to MIP (r = 0.809,p <0.001) and MIG (r = 0.773, p <0.001). Of the 3 monokines, TNF{alpha} and MIG levels were related to monocyte count, but none showed correlation with lymphocyte count in cancer patients. In patients with bacterial infection,TNF{alpha} was not significantly related to MIP (r = 0.423, p = 0.051), but it was related to MIG (r = 0.457; p = 0.033). None of the monokines (TNF{alpha}, MIP, MIG) was related to the monocyte count, but the MIP level was related to the peripheral blood lymphocyte count in patients with bacterial infection (r = 0.559, p = 0.008). These results suggest that circulating monocytes may play an important role in both cancer and bacterial infection through increased production of monokines. Moreover, correlations of the monokine levels with each other and their relationships to the monocyte count differ in patients with cancer and bacterial infection.

Keywords: TNF{alpha}, MIP, MIG, cancer, bacterial infection




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