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Annals of Clinical & Laboratory Science 33:97-100 (2003)
© 2003 Association of Clinical Scientists

Case Report

IgD-Kappa Myeloma: An Unusual Case

Amy M. Tharp, Ralph D. Woodruff and Zak K. Shihabi
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Address correspondence to Zak K. Shihabi, Ph.D., Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; tel 336 716 2639; fax 336 716 9944; e mail zshihabi{at}wfubmc.edu.

Abstract

A rare case of biclonal IgD-K and IgG-K myeloma is described. The patient initially presented with anemia, renal insufficiency, and proteinuria. The IgD-K, initially, was overlooked as a light chain; however, it decreased in serum concentration after treatment by ~90%, in contrast to the IgG-K that decreased in serum by ~40 % over a 9-yr period. Clinically, the patient responded well to treatment and improved greatly during this period. Practical recommendations are suggested in order to detect such cases.

Keywords: myeloma, IgD, immunoglobulins, immunofixation, light chains






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