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Meningioangiomatosis: Report of Three Cases and Review of the Literature

Address correspondence to Peter M. Farmer, M.D., Department of Pathology, Long Island Jewish Medical Center, 70-05 76th Avenue, New Hyde Park, NY 11040, USA; tel 718 470 7193; fax 718 347 4866

Meningioangiomatosis is a rare condition, probably hamartomatous, characterized by proliferation of capillary-sized vessels, meningothelial cells, and fibroblasts within the cortex of the brain. Lesions may be single or diffuse and may be associated with neurofibromatosis type II. Clinically it presents with seizures but may be asymptomatic throughout life. We report 3 cases of meningioangiomatosis, 2 localized and 1 diffuse, all with different clinical manifestations. Differential diagnoses are discussed with a review of the literature. Since this condition is rare, close clinico-pathological correlation is essential. A correct diagnosis avoids further aggressive treatment.