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Annals of Clinical & Laboratory Science 32:406-413 (2002)
© 2002 Association of Clinical Scientists

HIV Resistance Testing: an Update

Jaber Aslanzadeh
Department of Laboratory Medicine, University of Connecticut Medical School, Farmington, Connecticut

Address correspondence to Jaber Aslanzadeh, Ph.D., Department of Pathology, Hartford Hospital, 80 Sycamore Street, Hartford, CT 06102-5037; USA; tel 860 545 4128; fax 860 545 2726; e-mail jaslanz{at}harthosp.org.

In recent years, resistance testing has become an important tool in optimizing the combination therapy for treating HIV infected individuals. The identification of resistance mutations has allowed physicians to select the antiviral agents with maximum therapeutic benefic and minimum toxic side effects. The current therapeutic agents approved by the Food and Drug Administration (FDA), their mechanisms of actions, and the mutations of the HIV viral genome that lead to resistance to antiviral agents are discussed. In addition, methods of resistance testing, both genotypic and phenotypic, are evaluated with consideration of their inherent advantages and disadvantages.

Keywords: HIV resistance testing, HIV mutations, antiviral agents, reverse transcriptase inhibitors






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Copyright © 2002 by the Association of Clinical Scientists.