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Annals of Clinical & Laboratory Science 32:305-308 (2002)
© 2002 Association of Clinical Scientists

Severe Hypocholesterolemia with Reduced Serum Lipoprotein(a) in a Patient with Visceral Leishmaniasis

Evagellos Liberopoulos1, George Alexandridis1, Eleni Bairaktari2 and Moses Elisaf1
1 Department of Internal Medicine, and 2 Laboratory of Biochemistry, University of Ioannina School of Medicine, Ioannina, Greece

Address correspondence to Moses Elisaf, M.D., Department of Internal Medicine, University of Ioannina, 451 10 Ioannina, Greece; tel 30 65 109 7509; fax 30 65 109 7016; e-mail: egepi{at}cc.uoi.gr.

We report the case of a 36-yr-old man with visceral leishmaniasis who presented with marked hypocholesterolemia, mild hypertriglyceridemia, severely decreased serum levels of HDL-cholesterol, LDL-cholesterol, apolipoproteins AI and B, and increased serum level of apolipoprotein E. Moreover, serum Lp(a) level was markedly reduced on presentation, which is the first published report on Lp(a) levels in kala-azar. Possible mechanisms for the observed alterations of the serum lipid profile are discussed.

Keywords: visceral leishmaniasis, kala-azar, hypocholesterolemia, lipid disorders, lipoprotein(a)




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