HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cogalgil, S. Articles by Taysi, S. Search for Related Content PubMed PubMed Citation Articles by Cogalgil, S. Articles by Taysi, S.

Levels of Antioxidant Proteins and Soluble Intercellular Adhesion Molecule-1 in Serum of Patients with Rheumatoid Arthritis

Address correspondence to Dr. Sirzat Cogalgil, Dept. of Physical Therapy and Rehabilitation, Ataturk University Medical School, PK. 45, 25020 Erzurum, Turkey; tel 90 442 236 0985; fax 90 442 236 0985; e-mail scogalgil{at}hotmail.com.

Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), ceruloplasmin (Cp), and transferrin (Tf) were measured in patients with rheumatoid arthritis (RA) and the correlations of these parameters with disease activity were investigated. Serum sICAM-1 levels were determined by a sandwich enzyme-linked immunosorbant assay (ELISA) in serums from 42 patients with RA and 30 healthy controls. Erythrocyte sedimentation rate (ESR) was determined by the Westergren method and C-reactive protein (CRP), Cp, and Tf by nephelometric methods. Disease activity was assessed by standard criteria. Serum Tf levels were significantly diminished and serum levels of sICAM-1 and Cp were significantly increased in patients with RA, compared to healthy controls. Serum sICAM-1 levels showed negative correlation with serum Tf levels (r = -0.47, p <0.01), and positive correlation with serum Cp levels (r = 0.49, p <0.001). There was weak positive correlation between sICAM-1 levels and the Ritche articular index (RAI) scores (r = 0.32, p <0.05) and serum CRP levels (r = 0.44, p <0.01), but no significant correlations of sICAM-1 levels with ESR, patient’s age, or duration of disease. There were no significant correlations between values of serum CRP, RAI score, or ESR with serum CP or Tf levels. This study indicates that serum sICAM-1, together with other parameters, is a useful and novel marker for evaluating the disease status and activity of patients with RA.

Keywords: soluble intercellular adhesion molecule-1, ceruloplasmin, transferrin, rheumatoid arthritis

This article has been cited by other articles:

				H. Ucuncu, B. Aktan, F. Ozabacigil, M. E. Buyukokuroglu, M. Akyuz, and E. Altas Protective Effect of Melatonin on Experimental Otitis Media with Effusion in Guinea Pigs Ann. Clin. Lab. Sci., July 1, 2004; 34(3): 341 - 346. [Abstract] [Full Text] [PDF]

				B. Aktan, S. Taysi, K. Gumustekin, N. Bakan, and Y. Sutbeyaz Evaluation of Oxidative Stress in Erythrocytes of Guinea Pigs with Experimental Otitis Media and Effusion Ann. Clin. Lab. Sci., April 1, 2003; 33(2): 232 - 236. [Abstract] [Full Text] [PDF]

				C. Uslu, S. Taysi, and N. Bakan Lipid Peroxidation and Antioxidant Enzyme Activities in Experimental Maxillary Sinusitis Ann. Clin. Lab. Sci., January 1, 2003; 33(1): 18 - 22. [Abstract] [Full Text] [PDF]

				S. Taysi, I. Kocer, R. Memisogullari, and A. Kiziltunc Serum Oxidant/Antioxidant Status in Patients with Behcet's Disease Ann. Clin. Lab. Sci., October 1, 2002; 32(4): 377 - 382. [Abstract] [Full Text] [PDF]